I used to work at a vitamin store part time and have tried a few different brands. The ones that seem to work the best for me are the food-derived vitamins from Garden of Life. Specfically, their new line called Kind Organics. They offer a one-a-day, 2-a-day and prenatal. I personally take the 2-a-day formula and the biggest difference I see when I take them is better sleep and more energy upon waking. Most of the studies that claim that MV's are useless and don't help fill nutritional gaps look at the cheap grocery store one-a-days. The RDA for most vitamins and minerals hasn't been reviewed/updated in quite a while. With our hectic society and way of life, we need way more than 100% RDA of many vitamins and minerals. It's best to not rely on supplements though. Try eating nothing but vegetables, fruits, whole grains, lean meats, and organic dairy for a while and you'll feel like a million bucks.