I would personally recommend against Wheel Brightner in this situation, because you wheels are `rashed` and it appears some of the bare metal is showing (assuming aluminum). Wheel Brightner could work well on the staining, but could damage the aluminum (highly corrosive) if exposed.
Because of the severity of that staining (and the fact that other wheel cleaners didn`t even touch it) you are will likely need oxalic acid, which used to be found some of the old Chrome Wheel Cleaners.
I believe Mother`s still sells a wheel cleaner (in bulk size) that contains oxalic acid, I don`t believe anything we sell uses it. Dilute 1:1 with water and brush on with a stiff toothbrush. The oxalic acid will eat the rust and destroy the bond that is holding the brake dust on, you maybe have to apply it a couple times with the toothbrush and let it dwell as it works.
The problem is that once you remove the staining you may find that the clear coat underneath is damaged from the brake dust and neglect.
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